Swallow Prednisolone tablets whole (do not chew) with water. Take your tablets with or after food. Adults and Elderly: Your doctor may start your treatment with the lowest dose for a minimum period of time to minimize side effects. Your doctor may decide to start your treatment with Prednisolone at a dose of 5mg to 60mg taken daily either in several doses throughout the day, or as a single dose in the morning after breakfast, or as a double dose on alternate days. The dose may be lowered after a few days to 2.5mg to 15mg per day, but your doctor may decide higher doses may be needed for several weeks or months. Use in children: Prednisolone may be given to children very rarely to treat specific conditions. The smallest dose may be given for the shortest time possible.